Effectiveness of Combined Preoperative Sublingual Misoprostol and Intravenous Tranexamic Acid on Intraoperative Blood Loss During Elective Caesarean Section: A Randomised, Blinded, Placebo-Controlled Trial

Introduction: The objective of this study was to evaluate the effect preoperative administration sublingual misoprostol and intravenous tranexamic acid (TXA) on intraoperative blood loss during elective caesarean sections. Methods: This a double-blinded, randomised, placebo-controlled involving 116 women scheduled for treatment arm, group 1 (n=58), received 1000 mg 10-15 minutes before skin incision 600 mcg after sub-arachnoid anaesthesia incision. Group 2 (n=58) placebos; both groups had oxytocin injections at delivery placenta. data were analyzed using IBM® Statistical Package Social Sciences (SPSS) version 24 (IBM Corp., Armonk, NY). Results: primary outcome difference between postoperative hematocrit values in groups. mean significantly lower than control (308.552 ± 42.991 mL versus 736.414 171.889 mL, p<0.001). differences post-operative also (2.212% 0.805% 5.660% 2.496%, Conclusion: Preoperative reduced related delivery.